All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay
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چکیده
منابع مشابه
Mechanisms of Bacterial Transcription Termination: All Good Things Must End.
Transcript termination is essential for accurate gene expression and the removal of RNA polymerase (RNAP) at the ends of transcription units. In bacteria, two mechanisms are responsible for proper transcript termination: intrinsic termination and Rho-dependent termination. Intrinsic termination is mediated by signals directly encoded within the DNA template and nascent RNA, whereas Rho-dependen...
متن کاملWays and means of eukaryotic mRNA decay.
Messenger RNA degradation is an important point of control for gene expression. Genome-wide studies on mRNA stability have demonstrated its importance in adaptation and stress response. Most of the key players in mRNA decay appear to have been identified. The study of these proteins brings insight into the mechanism of general and specific targeting of transcripts for degradation. Recruitment a...
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متن کامل"All Good Things Must Come to an End"
Turning off signaling pathways can be just as important for proper biological regulation as turning them on. The Notch signaling pathway controls development of the nervous system in Drosophila. Proteolysis of Notch appears to initiate signaling, but further proteolysis may also terminate signals from this pathway. Kopan discusses mechanisms that limit signaling by Notch, including recent evide...
متن کاملThe lognormal distribution fits the decay profile of eukaryotic mRNA.
A general program was written which simulates radioactive labeling of RNA in viva. The program was used to determine the effect that different -distributions of half-lives would have on the composite decay curve observed in a pulse-chase experiment. Four biologically relevant points emerge: 1) The published, experimentally determined composite decay curves for eukaryotic mRNA are not compatible...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2010
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2917